A Biomonitoring Pilot Study in Workers from a Paints Production Plant Exposed to Pigment-Grade Titanium Dioxide (TiO2)

Among particulate matter composing paints, titanium dioxide (TiO2) forms about 20% of the final suspension. Although TiO2 is broadly used in many applications, TiO2 powders represent an established respiratory hazard for workers with long-term exposure.

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Evaluation of potential engineered nanomaterials impacts on human health: from risk for workers to impact on consumers

Within the project, a collaborative book chapter (review) has been published, acknowledging NANOExplore: Chapter 10 - Evaluation of potential engineered nanomaterials impacts on human health: from risk for workers to impact on consumers. By M.G. Bianchi, O. Bussolati, M. Chiu, G. Taurino, E. Bergamaschi. In: Exposure to Engineered Nanomaterials in the Environment - Micro and Nano Technologies, 2019, Pages 263-287. Available online 31 May 2019.

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In vitro Validation of causal link between nanomaterial and selected biomarkers in human workers

Resulting from task B.2.3 (In vitro Validation of causal link between nanomaterial and selected biomarkers in human workers) of the NanoExplore project several articles have been published

Reference Ranges of 8-Isoprostane Concentrations in Exhaled Breath Condensate (EBC): A Systematic Review and Meta-Analysis
Reference ranges of oxidative stress biomarkers selected for non-invasive biological surveillance of nanotechnology workers: Study protocol and meta-analysis results for 8-OHdG in exhaled breath condensate
Urinary 8-isoprostane as a biomarker for oxidative stress. A systematic review and meta-analysis
Urinary 8-OHdG as a Biomarker for Oxidative Stress: A Systematic Literature Review and Meta-Analysis

Inflammatory Biomarkers in Exhaled Breath Condensate: A Systematic Review

Inflammation is a comprehensive set of physiological processes that an organism undertakes in response to a wide variety of foreign stimuli, such as viruses, bacteria, and inorganic particles. A key role is played by cytokines, protein-based chemical mediators produced by a broad range of cells, including the immune cells recruited in the inflammation site. The aim of this systematic review is to compare baseline values of pro/anti-inflammatory biomarkers measured in Exhaled Breath Condensate (EBC) in healthy, non-smoking adults to provide a summary of the concentrations reported in the literature.

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NANOExplore: State of knowledge on the occupational exposure to carbon nanotubes

Within the consortium, a paper has been published, acknowledging NANOExplore: State of knowledge on the occupational exposure to carbon nanotubes. By I. Guseva Canu, K. Batsungnoen, A. Maynard, N.B. Hopf. In: Elsevier International Journal of Hygiene and Environmental Health, Volume 225, April 2020.

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Occupational Exposure to Carbon Nanotubes and Carbon Nanofibres: More Than a Cobweb

The review´s topic is a risk assessment for carbon nanotubes (CNTs) and carbon nanofibers (CNFs), regarding their biological activity and their hazardous effects in humans. The aim of this review is to challenge the conception of CNTs/CNFs as a single, unified material entity and prompt the establishment of standardized hazard and exposure assessment methodologies able to properly feed risk assessment and management frameworks.

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